PCOS Weight Loss & Obesity
Weight Loss with PCOS is possible! Learn why it’s different for women with PCOS and explore our evidence backed customized program for PCOS weight loss.
PCOS Weight Loss: Why the Struggle is Different
For many women, losing weight is already a challenge—but with PCOS, it can feel nearly impossible. Hormonal imbalances, insulin resistance, and metabolic changes all play a role in making weight loss with PCOS uniquely difficult. At PCOS Sisters Telehealth Clinic & Wellness Center, we understand these struggles firsthand—because our providers have PCOS too.
That’s why our approach to PCOS weight loss is never one-size-fits-all. We offer multiple pathways to help you achieve your goals, whether through lifestyle coaching, nutrition and fitness support, or medications such as GLP-1s when appropriate. Together, we’ll create a plan that fits your body, your health needs, and your life.
PCOS Sisters' Telehealth PCOS Metabolic Weight Loss Program™
The PCOS Sisters’ Telehealth PCOS Metabolic Weight Loss Program™ is backed by early program evaluation data in collaboration with Emory University School of Nursing. This innovative approach combines the proven benefits of GLP-1 agonists with lifestyle management, all delivered through the convenience of telehealth.
These preliminary results were presented at the AE-PCOS Annual Meeting 2025. Visit our Research Page to follow updates and see the published outcomes once available.
Disclaimer: Our clinical weight loss program is informed by a retrospective chart review and early program evaluation. Evaluation conducted in collaboration with Emory University School of Nursing. Manuscript submission to peer review journal in progress. Weight loss results will vary from individual to individual and are not guaranteed.
About Obesity & Weight Loss with PCOS
Weight fluctuations are a natural part of life, and there are certain periods and events that can cause extra weight to pile on. Medical conditions, including PCOS, can also make weight gain appear to happen for “no reason.”
At PCOS Sisters Telehealth Clinic & Wellness Center, your medical weight loss journey begins with a thorough evaluation and lab work to uncover the root cause of your weight gain. If PCOS is the cause, we’ll tailor your treatment to address it. And if it isn’t, we can still provide the tools and strategies you need to successfully lose weight.
Every plan is designed around you, starting with a personalized diet and exercise program and, when appropriate, medication to balance hormones and support progress. Our clinical team guides you each step of the way so you never feel like you’re navigating this journey alone.
Treatments for Weight Loss
When you start to gain weight without any changes being made to your diet or daily routine, it can cause a lot of grief and uncertainty. But rest assured that you have options to help you return to a weight you feel comfortable with. Managing the cause of your PCOS can help regulate your weight, but we also offer treatments to address weight gain individually. Semaglutide is just one medication offered to treat PCOS and obesity.
Before & After
Symptoms
Procedure Details
The patient pictured lost 52 pounds in 6 months utilizing the PCOS Sisters Treatment Program. She used a combination of medications, diet, and exercise to lose weight and keep it off. She also experienced improvement in unwanted hair, improved energy levels, & hypertension.
How It Works
Personalized PCOS Exercise and Diet Plan
PCOS Sisters Telehealth Clinic & Wellness Center provides primary healthcare and treatment for women with polycystic ovarian syndrome. One component of the program is metabolic optimization achieved through a personalized PCOS exercise and diet plan. Our PCOS Specialized Nurse Practitioner and Health Coach will customize your unique workouts, which you can access online or through your smartphone.
What platforms do you use for the fitness and diet plan?
We have developed our own PCOS Sisters Fitness App. Our app offers a nutrition platform with custom exercise videos, fitness targets, body stats, tracking, rewards, PCOS support community, as well as daily personalized meal plans designed for PCOS women.
- PCOS Sisters Fitness App Features & Benefits
- Loyalty Rewards for working out
- exercise videos
- fitness targets
- body stats
- tracking
- PCOS Support Community where you chat with other PCOS Sister patients
- Daily personalized meal plan recipes with cooking videos.
- All designed for PCOS women
PCOS Sisters Telehealth Clinic & Wellness Center
Your health is our priority
Obesity & PCOS Weight Loss FAQ's
Most weight loss occurs in the first 3 – 6 months of starting weight loss program. Even after you have reached a weight you feel comfortable and confident with, it will be important to stay on top of your nutrition and diet plan. If using Semaglutide weekly injections, you can expect to lose around 10 lbs per month. It is not safe to go beyond this rate of weight loss.
Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and a Glucagon-like peptide-1 (GLP-1) receptor agonist. In other words, Tirzepatide targets 2 receptors whereas semaglutide targets one receptor (GLP-1). What does this mean clinically? Studies show that at max dosage patient using Tirzepatide saw 17.8% weight loss while patients using semaglutide saw a 12.4% weight loss. This is a 5.4% increase in effectiveness, which statistically speaking isn’t a lot. It’s impossible to predict the genetic variation in receptors a patient may have. Some patients do better on semaglutide and others on Tirzepatide. If the results are not what you are expecting on one medication, it might be worth switching from Semaglutide to Tirzepatide or vice versa to see if it produces a better effect. Tirzepatide generally costs a bit more, so that is also a factor to consider.
Semaglutide is a GLP-1 agonist that targets receptors in the stomach to slow emptying making you feel full longer, stimulates the pancreas to release more insulin helping you process carbs, and reduces sugar production in the liver. All of these effects help to lower your cholesterol, prevent fatty liver, as well as reduce risk for diabetes and stroke. Semaglutide research is ongoing to determine it's potential use as a neuroprotective agent to prevent Alzheimer's and Parkinson's disease. Given it is used to increase insulin sensitivity, semaglutide is an ideal medication to treat not only obesity in PCOS patients, but it also treats the root cause of PCOS....Testosterone. By decreasing insulin resistance, testosterone levels are balanced.
Semaglutide is now included as a recommended treatment in the 2023 PCOS Management Guidelines.
Most weight loss occurs in the first 3 – 6 months of starting weight loss program. Even after you have reached a weight you feel comfortable and confident with, it will be important to stay on top of your nutrition and diet plan. If using Semaglutide weekly injections, you can expect to lose around 10 lbs per month. It is not safe to go beyond this rate of weight loss.
Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and a Glucagon-like peptide-1 (GLP-1) receptor agonist. In other words, Tirzepatide targets 2 receptors whereas semaglutide targets one receptor (GLP-1). What does this mean clinically? Studies show that at max dosage patient using Tirzepatide saw 17.8% weight loss while patients using semaglutide saw a 12.4% weight loss. This is a 5.4% increase in effectiveness, which statistically speaking isn’t a lot. It’s impossible to predict the genetic variation in receptors a patient may have. Some patients do better on semaglutide and others on Tirzepatide. If the results are not what you are expecting on one medication, it might be worth switching from Semaglutide to Tirzepatide or vice versa to see if it produces a better effect. Tirzepatide generally costs a bit more, so that is also a factor to consider.
Semaglutide is a GLP-1 agonist that targets receptors in the stomach to slow emptying making you feel full longer, stimulates the pancreas to release more insulin helping you process carbs, and reduces sugar production in the liver. All of these effects help to lower your cholesterol, prevent fatty liver, as well as reduce risk for diabetes and stroke. Semaglutide research is ongoing to determine it's potential use as a neuroprotective agent to prevent Alzheimer's and Parkinson's disease. Given it is used to increase insulin sensitivity, semaglutide is an ideal medication to treat not only obesity in PCOS patients, but it also treats the root cause of PCOS....Testosterone. By decreasing insulin resistance, testosterone levels are balanced.
Semaglutide is now included as a recommended treatment in the 2023 PCOS Management Guidelines.